One Ring to Fight Them All: The Sulfazecin Story. Issue 1 (19th January 2017)

• Record Type: Journal Article
• Authors: Braga, Daniel; Lackner, Gerald
• Is Part Of: Cell chemical biology. Volume 24:Issue 1(2017)
• Page Start: 1
• Page End: 2
• Publication Date: 2017-01-19
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2017.01.001
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : In this issue of Cell Chemical Biology, Li et al. (2017) report on the biosynthesis of the monobactam sulfazecin by Pseudomonas acidophila and hypothesize a novel mechanism of β-lactam ring formation. As monobactam antibiotics are unaffected by some emerging resistance mechanisms (particularly metallo-β-lactamases), this discovery opens prospects to engineer β-lactam antibiotics against multi-drug resistant pathogens. Abstract : In this issue of Cell Chemical Biology, Li et al. (2017) report on the biosynthesis of the monobactam sulfazecin by Pseudomonas acidophila and hypothesize a novel mechanism of β-lactam ring formation. As monobactams antibiotics are unaffected by some emerging resistance mechanisms (particularly metallo-β-lactamases), this discovery opens prospects to engineer β-lactam antibiotics against multi-drug resistant pathogens.