Microwave Selective Heating Enhancement for Cancer Hyperthermia Therapy Based on Lithographically Defined Micro/Nanoparticles. Issue 3 (25th May 2016)

• Record Type: Journal Article
• Authors: Wang, Yifei; Stang, John; Yu, Meng; Tsvetkov, Maksym; Wu, Chi‐Chan; Qin, Xuan; Chung, Eugene; Moghaddam, Mahta; Wu, Wei
• Is Part Of: Advanced materials technologies. Volume 1:Issue 3(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-05-25
• Subjects: cancer hyperthermia therapy -- lithographically defined micro/nanoparticle -- magnetic dipole -- microwave absorption -- selective heating enhancement; Materials science -- Periodicals; Technological innovations -- Periodicals; Materials science; Technological innovations; Periodicals; 620.1105
• DOI: 10.1002/admt.201600038
• Languages: English
• ISSNs: 2365-709X

Abstract

Abstract : Hyperthermia therapy is a promising approach for cancer treatment that uses external electromagnetic fields to heat up the tumor region in order to preferentially weaken or kill cancer cells. However, achieving localized heating of the cancer tissue without damaging the nearby healthy tissue remains a challenge. This study proposes to use lithographically defined micro/nanoparticles as microwave absorbers to achieve localized heating under microwave radiation for hyperthermia therapy. The particle structures, including both geometry and material, have been designed, tested, and optimized by the finite element method using Ansoft HFSS to obtain high microwave absorption efficiency. Based on the numerical studies, the magnetic dipoles have been chosen as the microwave‐absorbing particles. The fabrication and collection processes of the particles have been developed. The measurements in this study, based on particle‐suspended hydrogel setup, have demonstrated that the micro/nanoparticles can absorb the external electromagnetic field efficiently and greatly enhance the localized heat generation compared to control groups without particles. Abstract : Lithographically defined micro/nanoparticles have been investigated by Y. F. Wang, W. Wu, and co‐workers with high microwave absorption efficiency through magnetic coupling for cancer hyperthermia therapy. The fabrication and collection approaches for the particles have been developed and heating enhancement effects have been demonstrated. The particles exhibit a great potential in medical applications for selectively localized hyperthermia treatments.