The Esophagiome: concept, status, and future perspectives. Issue 1 (29th August 2016)

• Record Type: Journal Article
• Authors: Gregersen, Hans; Liao, Donghua; Brasseur, James G.
• Other Names: Giuli Robert guestEditor.; Gregersen Hans guestEditor.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1380:Issue 1(2016)
• Page Start: 6
• Page End: 18
• Publication Date: 2016-08-29
• Subjects: Esophagiome -- GIOME -- esophagus -- esophagogastric junction -- modeling -- biomechanics -- gastrointestinal -- neurophysiology -- peristalsis; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.13200
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract : The term "Esophagiome" is meant to imply a holistic, multiscale treatment of esophageal function from cellular and muscle physiology to the mechanical responses that transport and mix fluid contents. The development and application of multiscale mathematical models of esophageal function are central to the Esophagiome concept. These model elements underlie the development of a "virtual esophagus" modeling framework to characterize and analyze function and disease by quantitatively contrasting normal and pathophysiological function. Functional models incorporate anatomical details with sensory–motor properties and functional responses, especially related to biomechanical functions, such as bolus transport and gastrointestinal fluid mixing. This brief review provides insight into Esophagiome research. Future advanced models can provide predictive evaluations of the therapeutic consequences of surgical and endoscopic treatments and will aim to facilitate clinical diagnostics and treatment.