Ongoing adaptive immune responses in the microenvironment of melanoma metastases. (7th May 2013)

• Record Type: Journal Article
• Authors: van Baren, Nicolas; Coulie, Pierre G.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1284(2013)
• Page Start: 62
• Page End: 65
• Publication Date: 2013-05-07
• Subjects: melanoma -- metastasis -- lymphoid neogenesis -- germinal center -- humoral response -- IgA; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.12093
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract : A large body of evidence supports the idea that the tumor environment is immunosuppressive, notably for T lymphocytes. Yet, in some tumor types, the presence of tumor‐infiltrating T cells has favorable prognostic value. In order to better understand the functional value of T cells in human tumors, we focused on cutaneous metastases of melanoma and observed that some of them host ectopic lymphoid structures in which B cell, and possibly T cell, responses take place. This observation is discussed in the context of current views on immunosuppression in tumors.