The pig as a valuable model for testing the effect of resveratrol to prevent cardiovascular disease. (15th July 2013)

• Record Type: Journal Article
• Authors: Elmadhun, Nassrene Y.; Sabe, Ashraf A.; Robich, Michael P.; Chu, Louis M.; Lassaletta, Antonio D.; Sellke, Frank W.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1290(2013)
• Page Start: 130
• Page End: 135
• Publication Date: 2013-07-15
• Subjects: resveratrol -- myocardial ischemia -- pig model -- cardiovascular disease -- metabolic syndrome; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.12216
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract : Resveratrol is a naturally occurring polyphenol found in the skin of red grapes, peanuts, and red wine that has been shown to modify many cardiovascular risk factors. Small animal models have been extensively used to investigate cardiovascular disease, but the results often fail to translate in clinical trials. Disease‐specific pig models are emerging as clinically useful tools that may offer insight into cardiovascular disease and the effect of drugs such as resveratrol on cardiovascular health. In this paper, we discuss the advantage of using clinically relevant pig models of diabetes, hypercholesterolemia, and myocardial ischemia to investigate the role of resveratrol in cardiovascular disease prevention.