Evidence for circulatory benefits of resveratrol in humans. (15th July 2013)

• Record Type: Journal Article
• Authors: Wong, Rachel H.X.; Coates, Alison M.; Buckley, Jonathan D.; Howe, Peter R.C.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1290(2013)
• Page Start: 52
• Page End: 58
• Publication Date: 2013-07-15
• Subjects: resveratrol -- flow‐mediated dilation -- endothelial function -- human -- vasodilator responsiveness -- trans‐resveratrol; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.12155
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract : Impairments of endothelial function, which can be assessed noninvasively by flow‐mediated dilation (FMD) of the brachial artery, contribute to the development of cardiovascular disease. Associations between FMD and cognition suggest a vascular component in the loss of cognitive function. Certain vasoactive nutrients that have been shown to improve FMD may also have the potential to enhance cerebral perfusion and cognition. Preclinical studies show that trans ‐resveratrol can enhance nitric oxide bioavailability, thereby increasing endothelium‐dependent vasodilation. We have now shown that acute administration of resveratrol elicits dose‐dependent increases of FMD with greater potency than other vasoactive nutrients and that this benefit is sustained following regular consumption. We describe the potential implications of this vasodilator benefit of resveratrol and its role in enhancing cerebrovascular and cognitive functions.