Laser Ablation of Recurrent Malignant Gliomas: Current Status and Future Perspective. (December 2016)

• Record Type: Journal Article
• Authors: Rodriguez, Analiz; Tatter, Stephen B.
• Is Part Of: Neurosurgery. Volume 79:(2016)Supplement 1
• Publication Date: 2016-12
• Subjects: Glioblastoma -- Laser thermal therapy -- Recurrent malignant glioma -- Stereotactic laser ablation; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1227/NEU.0000000000001442
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract : Recurrent malignant glioma continues to be a clinical challenge, and repeat surgery is an option in only select patients. Stereotactic laser ablation, a new minimally invasive technique, can be used as an alternative to surgery. We review the current literature on laser ablation for recurrent malignant gliomas as well as discuss practical and theoretical advantages and disadvantages of this emerging technique in comparison with repeat surgery or radiation. We also discuss the potential for laser ablation to augment adjuvant therapies, namely, chemotherapy, radiation, and immunotherapy. ABBREVIATIONS: BBB, blood-brain barrier BVZ, bevacizumab HGG, high-grade glioma LITT, laser interstitial thermotherapy TMZ, temozolomide