Copper(ii) carboxymethylcellulose (CMC-CuII) as an efficient catalyst for aldehyde–alkyne–amine coupling under solvent-free conditions. Issue 97 (4th October 2016)

• Record Type: Journal Article
• Authors: Liu, Xiaoping; Lin, Bijin; Zhang, Zhuan; Lei, Hao; Li, Yiqun
• Is Part Of: RSC advances. Volume 6:Issue 97(2016)
• Page Start: 94399
• Page End: 94407
• Publication Date: 2016-10-04
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra18742k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A novel heterogeneous Cu(ii ) carboxymethylcellulose catalyst was prepared and successfully employed in the A3 coupling without using any co-catalyst, other additives, bases under solvent-free conditions. Abstract : A novel and eco-friendly three-component reaction of aldehydes, amines, and alkynes (A3 coupling) catalyzed by a recoverable copper(ii ) carboxymethylcellulose (CMC-Cu II ) catalyst has been developed, producing a diverse range of propargylamines under solvent-free conditions in good yields. The CMC-Cu II catalyzed reaction is especially effective for reactions involving aromatic and aliphatic aldehydes. High catalytic activity was obtained in the presence of 5 mol% CMC-Cu II without any other co-catalyst, additives, or bases under aerobic conditions. Moreover, the catalyst can be easily recovered and reused for at least four cycles without significant decrease in its catalytic activity.