Functional proteomic insights in B-cell chronic lymphocytic leukemia. (1st February 2017)

• Record Type: Journal Article
• Authors: Díez, Paula; Góngora, Rafael; Orfao, Alberto; Fuentes, Manuel
• Is Part Of: Expert review of proteomics. Volume 14:Number 2(2017)
• Page Start: 137
• Page End: 146
• Publication Date: 2017-02-01
• Subjects: Chronic lymphocytic leukemia -- proteomics -- signaling pathways -- CLL heterogeneity -- cytogenetics; Proteins -- Biotechnology -- Periodicals; Proteomics -- Periodicals; 572.6
• DOI: 10.1080/14789450.2017.1275967
• Languages: English
• ISSNs: 1478-9450

Abstract

ABSTRACT: Introduction : B cell chronic lymphocytic leukemia (B-CLL) is a hematological malignancy considered as the most common leukemia in the Western world. The understanding of B cell differentiation is crucial for the diagnosis, prognosis, and treatment of the disease. Areas covered : In this review, B-cell ontogeny and its relation with the CLL development, in combination with the proteomic approaches which could provide a deep characterization of the disease through the characterization of the cellular signaling pathways involved in the pathological cells is described. Expert commentary : Although conventional strategies (genome sequencing, morphology assays, and immunophenotyping by flow cytometry and/or immunochemistry) have allowed the establishment of the disease stage based on different parameters, it is still necessary to utilize novel approaches (e.g., proteomics) that have the potential to simultaneously analyze thousands of molecules to improve understanding of CLL.