T-cell subsets in lymph nodes identify a subgroup of follicular lymphoma patients with favorable outcome. Issue 4 (3rd April 2017)

• Record Type: Journal Article
• Authors: Magnano, Laura; Martínez, Antonio; Carreras, Joaquim; Martínez-Trillos, Alejandra; Giné, Eva; Rovira, Jordina; Dlouhy, Ivan; Baumann, Tycho; Balagué, Olga; Campo, Elías; López-Guillermo, Armando; Villamor, Neus
• Is Part Of: Leukemia & lymphoma. Volume 58:Issue 4(2017)
• Page Start: 842
• Page End: 850
• Publication Date: 2017-04-03
• Subjects: Follicular lymphoma -- prognosis -- CD4+CD57+ cells; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2016.1217525
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: We have analyzed in lymph nodes at diagnosis of 75 patients with follicular lymphoma (FL) the relationship between different T-cell subpopulations, assessed by immunohistochemistry (IHC) and flow cytometry (FC), with the outcome. CD4 + cells were the most abundant T-cells in tumor tissue sections, whilst CD57 + cells were the less frequent. In addition to nonambulatory performance status, advanced stage and FLIPI, low CD4 + CD57 + /CD4 + ratio ( p = .041), and low CD4 + /CD8 + ratio ( p = .008) predicted poor overall survival (OS). Multivariate analysis showed that CD4 + CD57 + /CD4 + ratio was the most important variable for OS. In conclusion, T-cell subpopulations, including CD4 + CD57 + /CD4 + ratio analyzed by FC, could identify FL patients with favorable outcome.