Concomitance of monosomal karyotype with at least 5 chromosomal abnormalities is associated with dismal treatment outcome of AML patients with complex karyotype – retrospective analysis of Polish Adult Leukemia Group (PALG). Issue 4 (3rd April 2017)

• Record Type: Journal Article
• Authors: Wierzbowska, Agnieszka; Wawrzyniak, Ewa; Siemieniuk-Rys, Monika; Kotkowska, Aleksandra; Pluta, Agnieszka; Golos, Aleksandra; Robak, Tadeusz; Szarawarska, Marta; Jaskowiec, Anna; Duszenko, Ewa; Rybka, Justyna; Holojda, Jadwiga; Grosicki, Sebastian; Pienkowska-Grela, Barbara; Woroniecka, Renata; Ejduk, Anna; Watek, Marzena; Wach, Malgorzata; Mucha, Barbara; Skonieczka, Katarzyna; Czyzewska, Maria; Jachalska, Anna; Klonowska, Agnieszka; Iliszko, Mariola; Knopinska-Posluszny, Wanda; Jarmuz-Szymczak, Malgorzata; Przybylowicz-Chalecka, Anna; Gil, Lidia; Kopacz, Agnieszka; Holowiecki, Jerzy; Haus, Olga;
• Is Part Of: Leukemia & lymphoma. Volume 58:Issue 4(2017)
• Page Start: 889
• Page End: 897
• Publication Date: 2017-04-03
• Subjects: Acute myeloid leukemia -- complex karyotype -- monosomal karyotype -- prognosis -- cladribine; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2016.1219901
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Monosomal karyotype (MK) and complex karyotype (CK) are poor prognostic factors in acute myeloid leukemia (AML). A comprehensive analysis of cytogenetic and clinical factors influencing an outcome of AML-CK + was performed. The impact of cladribine containing induction on treatment results was also evaluated. We analyzed 125 patients with AML-CK + treated within PALG protocols. MK was found in 75 (60%) individuals. The overall complete remission (CR) rate of 66 intensively treated patients was 62% vs. 28% in CK + MK − and CK + MK + group ( p = .01). No difference in CR rate was observed between DA and DAC arms. The overall survival (OS) in intensively treated patients was negatively influenced by MK, karyotype complexity (≥5 abnormalities), and WBC >20 G/L in multivariate analysis. The addition of cladribine to DA regimen improved OS only in MK − but not in MK + group. In conclusion, concomitance of MK with ≥5 chromosomal abnormalities is associated with dismal treatment outcome in AMK-CK + .