A Hyperpolarizable 1H Magnetic Resonance Probe for Signal Detection 15 Minutes after Spin Polarization Storage. Issue 50 (15th November 2016)

• Record Type: Journal Article
• Authors: Roy, Soumya S.; Norcott, Philip; Rayner, Peter J.; Green, Gary G. R.; Duckett, Simon B.
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 50(2016)
• Page Start: 15642
• Page End: 15645
• Publication Date: 2016-11-15
• Subjects: hyperpolarization -- long-lived singlet states -- NMR spectroscopy -- para-hydrogen -- structure elucidation; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201609186
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are two extremely important techniques with applications ranging from molecular structure determination to human imaging. However, in many cases the applicability of NMR and MRI are limited by inherently poor sensitivity and insufficient nuclear spin lifetime. Here we demonstrate a cost‐efficient and fast technique that tackles both issues simultaneously. We use the signal amplification by reversible exchange (SABRE) technique to hyperpolarize the target 1 H nuclei and store this polarization in long‐lived singlet (LLS) form after suitable radiofrequency (rf) pulses. Compared to the normal scenario, we achieve three orders of signal enhancement and one order of lifetime extension, leading to 1 H NMR signal detection 15 minutes after the creation of the detected states. The creation of such hyperpolarized long‐lived polarization reflects an important step forward in the pipeline to see such agents used as clinical probes of disease. Abstract : Magnetic resonance markers : The lifetimes of 1 H hyperpolarized NMR signals were extended by one‐order of magnitude from their normal levels to make possible their detection 15 minutes after the initial state creation step (see picture; RF=radiofrequency). This result was achieved by using a strongly coupled 1 H spin pair in a pyridazine‐based molecule.