Life in lights: Tracking mitochondrial delivery to lysosomes in vivo. Issue 12 (1st December 2016)

• Record Type: Journal Article
• Authors: McWilliams, Thomas G.; Ganley, Ian G.
• Is Part Of: Autophagy. Volume 12:Issue 12(2016)
• Page Start: 2506
• Page End: 2507
• Publication Date: 2016-12-01
• Subjects: autophagy -- brain -- development -- heart -- kidney -- mitochondria -- mitophagy -- tissues; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2016.1234567
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: The past decade has seen an intensive and concerted research effort into the molecular regulation of mitophagy, the selective autophagy of mitochondria. Cell-based studies have implicated mitophagy in the pathology of diverse conditions ranging from cancer to neurodegeneration. However, a definitive link between mitophagy and the etiology of human disease remains to be demonstrated. Moreover, we do not know how pervasive mammalian mitophagy is in vivo and fundamental questions remain unanswered. For example, is mitophagy common to all tissues under basal conditions or does it only occur in highly oxidative tissues under stress? This paucity of knowledge is largely due to a lack of experimentally tractable tools that can measure and monitor mitophagy in tissues. Our recent work describes the development of mito -QC, a mouse model to study mitophagy at single cell resolution in vivo.