Rhodium‐Catalyzed Diastereoselective Cyclization of Allenyl‐Sulfonylcarbamates: A Stereodivergent Approach to 1, 3‐Aminoalcohol Derivatives. (15th November 2016) - Spreider, Pierre A.
Abstract: A diastereoselective and stereodivergent rhodium‐catalyzed intramolecular coupling of sulfonylcarbamates with terminal allenes is described and it provides selective access to 1, 3‐aminoalcohol derivatives, scaffolds found in bioactive compounds. The reaction is compatible with a large range of different functional groups, thus furnishing products with high diastereoselectivities and yields. Moreover, multigram scale reactions, as well as the application of suitable product transformations were demonstrated.