Hyperammonemia: Liposome‐Supported Peritoneal Dialysis for the Treatment of Hyperammonemia‐Associated Encephalopathy (Adv. Funct. Mater. 46/2016). (12th December 2016)

• Record Type: Journal Article
• Authors: Agostoni, Valentina; Lee, Soo Hyeon; Forster, Vincent; Kabbaj, Meriam; Bosoi, Cristina R.; Tremblay, Mélanie; Zadory, Matthias; Rose, Christopher F.; Leroux, Jean‐Christophe
• Is Part Of: Advanced functional materials. Volume 26:Number 46(2016)
• Page Start: 8357
• Page End: 8357
• Publication Date: 2016-12-12
• Subjects: detoxification -- hepatic encephalopathy -- hyperammonemia -- liposomes -- peritoneal dialysis; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201670300
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : On page 8382, J.‐C. Leroux and co‐workers describe a novel approach for treating hyperammonemia induced encephalopathy, based on the peritoneal infusion of giant transmembrane pH‐gradient liposomes bearing an acidic core. These scavenging vesicles allow a safe and effective removal of excess ammonia, outperforming conventional peritoneal dialysis fluids and significantly attenuating brain edema in a rodent model of liver disease.