Efficacy and safety of triple therapy with aprepitant, ondansetron, and prednisone for preventing nausea and vomiting induced by R-CEOP or CEOP chemotherapy regimen for non-Hodgkin lymphoma: a phase 2 open-label, randomized comparative trial. Issue 4 (3rd April 2017)

• Record Type: Journal Article
• Authors: Song, Zheng; Wang, Huaqing; Zhang, Huilai; Zhao, Kuo; Zhang, Man; Yang, Fang
• Is Part Of: Leukemia & lymphoma. Volume 58:Issue 4(2017)
• Page Start: 816
• Page End: 821
• Publication Date: 2017-04-03
• Subjects: Aprepitant -- CINV -- CEOP regimen -- non-Hodgkin lymphoma; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2016.1213838
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: We performed a prospective study to investigate the efficacy and safety of triple therapy with aprepitant, ondansetron, and prednisone in non-Hodgkin lymphoma patients receiving R-CEOP or CEOP chemotherapy regimen. All patients were randomly assigned to either an aprepitant regimen (aprepitant plus ondansetron and prednisone), or a control regimen (ondansetron and prednisone) treatment group. For the complete response, the aprepitant group was statistically superior to the control group in the overall study period (76.5% vs. 56.0%; p = .03), as well as in separate analyses of the acute phase (92.2% vs. 78.0%; p = .045), and even more notably in the delayed phase (82.4% vs. 64.0%; p = .037). The overall incidence of adverse events was similar between the two treatment groups ( p > .05). The aprepitant regimen was more effective than the control regimen for the prevention of CINV in patients receiving R-CEOP or CEOP regimen and was generally well tolerated.