Lignan derivatives from Selaginella tamariscina and their nitric oxide inhibitory effects in LPS-stimulated RAW 264.7 cells. Issue 3 (1st February 2017)

• Record Type: Journal Article
• Authors: Dat, Le Duc; Zhao, Bing Tian; Hung, Nguyen Duc; Lee, Jeong Hyung; Min, Byung Sun; Woo, Mi Hee
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 3(2017)
• Page Start: 524
• Page End: 529
• Publication Date: 2017-02-01
• Subjects: Selaginella tamariscina -- Lignan -- Tamariscinosides D -- F -- NO production inhibition; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.12.028
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: The chemical characterization of Selaginella tamariscina leaves resulted in the isolation of five lignanoside derivatives (1 –4 and6 ) and one neolignan (5 ). These compounds include three new lignanosides, tamariscinosides D–F (1 –3 ), and one liriodendrin (4 ) that were isolated for the first time from this plant, together with two known compounds, (2 R, 3 S )-dihydro-2-(3, 5-dimethoxy-4-hydroxyphenyl)-7-methoxy-5-acetyl-benzofuran (5 ) and moellenoside B (6 ). The chemical structures of these isolated compounds were determined using 1D and 2D NMR, MS, and CD spectroscopic data, and the results were compared to data previously reported in the literatures. These compounds were also evaluated in terms of their inhibition of NO production in lipopolysaccharide (LPS)-stimulated activity in the macrophage cell line RAW 264.7. Among them, compounds1, 2, 5, and6 exhibited a significant inhibition with IC50 values ranging from 32.3 to 55.8 μM.