X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT. Issue 3 (1st February 2017)

• Record Type: Journal Article
• Authors: Topiol, Sid; Bang-Andersen, Benny; Sanchez, Connie; Plenge, Per; Loland, Claus J.; Juhl, Karsten; Larsen, Krestian; Bregnedal, Peter; Bøgesø, Klaus P.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 3(2017)
• Page Start: 470
• Page End: 478
• Publication Date: 2017-02-01
• Subjects: SERT serotonin transporter -- DAT dopamine transporter -- NAT noradrenaline transporter -- NSS neurotransmitter:sodium symporter -- SSRI selective serotonin reuptake inhibitor -- TCA tricyclic antidepressant -- dDAT Drosophila melanogaster DAT -- LeuT leucine transporter; Structure-based drug design -- Computer-aided drug discovery -- Docking -- X-ray structure -- SERT -- DAT -- LeuT; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.12.037
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: The recent publication of X-ray structures of SERT includes structures with the potent antidepressant S-Citalopram (S-Cit). Earlier predictions of ligand binding at both a primary (S1) and an allosteric modulator site (S2), were confirmed. We provide herein examples of a series of Citalopram analogs, showing distinct structure-activity relationship (SAR) at both sites that is independent of the SAR at the other site. Analogs with a higher affinity and selectivity than benchmark R-Citalopram (R-Cit) for the S2 versus the S1 site were identified. We deploy structural and computational analyses to explain this SAR and demonstrate the potential utility of the newly emerging X-ray structures within the neurotransmitter:sodium Symporter family for drug design.