Triterpene saponins and megastigmane glucosides from Camellia bugiamapensis. Issue 3 (1st February 2017)

• Record Type: Journal Article
• Authors: Huong, Nguyen Thi; Vien, Le Thi; Hanh, Tran Thi Hong; Dang, Nguyen Hai; Thanh, Nguyen Van; Cuong, Nguyen Xuan; Nam, Nguyen Hoai; Truong, Luu Hong; Ban, Ninh Khac; Kiem, Phan Van; Minh, Chau Van
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 3(2017)
• Page Start: 557
• Page End: 561
• Publication Date: 2017-02-01
• Subjects: Camellia bugiamapensis -- Theaceae -- NO production; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.12.020
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Highlights: The first phytochemical study on Camellia bugiamapensis was carried out. Two new saponins and two new megastigmane glycosides were isolated and elucidated. Camellioside I (1 ) showed moderate inhibition on NO production in RAW264.7 cells. Abstract: Two new triterpene saponins, camelliosides I and J (1 and2 ), two new megastigmane glycosides, camellistigosides A and B (3 and4 ), and two known megastigmane glycosides, icariside B1 (5 ) and (6 S, 9 R )-roseoside (6 ), were isolated from a methanol extract of the Camellia bugiamapensis leaves using various chromatographic separation techniques. Their structures were elucidated based on spectroscopic analyses, including HR ESI MS, CD, 1D and 2D NMR. Their inhibitory effects on LPS-induced NO production in RAW264.7 cells were evaluated. This is the first report of the chemical constituents and biological activity of C. bugiamapensis .