Effect of Nigella sativa L. seed extract on cisplatin-induced delay in gastric emptying in Sprague-Dawley rats. Issue 5 (4th March 2017)

• Record Type: Journal Article
• Authors: Riyaz, Ambreena; Nazir, Shahid; Khushtar, Mohammad; Mishra, Anuradha; Jahan, Yasmeen; Ahmad, Asad
• Is Part Of: Natural product research. Volume 31:Issue 5(2017)
• Page Start: 588
• Page End: 592
• Publication Date: 2017-03-04
• Subjects: Nigella sativa L -- gastric emptying -- cisplatin -- ondansetron; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1201670
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The aim of this study was focused on investigating the possible protective effect of Nigella sativa L. seed extract against cisplatin-induced delay in gastric emptying, in a rat model. Twenty-five male Sprague-Dawley rats were divided into five equal groups as follows: Group I or control group, Group II (cisplatin 10 mg/kg, i.p at day 5), Group III ( N. sativa L. 250 mg/kg for 5 days + cisplatin 10 mg/kg, i.p on day 5), Group IV ( N. sativa L . 500 mg/kg for 5 days + cisplatin 10 mg/kg, i.p on day 5) and Group V (ondansetron 3 mg/kg/day, per os + cisplatin 10 mg/kg, i.p on day 5). Phenol red meal was adopted to estimate gastric emptying in different groups of the rats. Gastric emptying was significantly increased ( p < 0.01) in N. sativa L. seed extract-pretreated rats (Group III and Group IV) when compared to cisplatin treatment alone (Group II). However, ondansetron produced significantly ( p < 0.01) better reversal than N. sativa L. seed extract. Abstract :