Efficient synthesis of 2, 3-dihydroquinazolin-4(1H)-ones catalyzed by titanium silicon oxide nanopowder in aqueous media. Issue 2 (17th January 2017)

• Record Type: Journal Article
• Authors: Mekala, Ramamohan; Madhubabu, M. V.; Dhanunjaya, G.; Regati, Sridhar; Chandrasekhar, K. B.; Sarva, Jayaprakash
• Is Part Of: Synthetic communications. Volume 47:Issue 2(2017)
• Page Start: 121
• Page End: 130
• Publication Date: 2017-01-17
• Subjects: Green chemistry -- nanopowder -- nitrogen heterocycles -- quinazolinones -- reusable catalyst; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2016.1254801
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: An efficient synthesis of 2, 3-dihydroquinazolin-4(1 H )-one derivatives is accomplished in aqueous media by a three-component reaction of isatoic anhydride, primary amines or ammonium acetate, and aldehydes catalyzed by titanium silicon oxide nanopowder. A variety of 2, 3-dihydroquinazolin-4(1 H )-one derivatives were synthesized using this methodology in good to excellent yields. The catalyst was recovered and recycled up to four times without significant loss in the catalytic activity. GRAPHICAL ABSTRACT: