Biomimetic fabrication of biocompatible and biodegradable core–shell polystyrene/biosurfactant bionanocomposites for protein drug release. Issue 8 (3rd January 2013)

• Record Type: Journal Article
• Authors: Hazra, Chinmay; Arunbabu, Dhamodaran; Kundu, Debasree; Chaudhari, Ambalal; Jana, Tushar
• Is Part Of: Journal of chemical technology & biotechnology. Volume 88:Issue 8(2013:Aug.)
• Page Start: 1551
• Page End: 1560
• Publication Date: 2013-01-03
• Subjects: polystyrene nanoparticles -- biosurfactants -- biocompatibility -- biodegradability -- emulsion polymerization; Biotechnology -- Periodicals; Chemistry, Technical -- Periodicals; Chemical engineering -- Periodicals; Industries -- Environmental aspects -- Periodicals; 660
• DOI: 10.1002/jctb.4003
• Languages: English
• ISSNs: 0268-2575

Abstract

Abstract: BACKGROUND: This paper reports a bioinspired emulsion polymerization approach through biosurfactants (rhamnolipid and surfactin) templating for synthesizing highly monodisperse, spherical polymer bionanocomposites consisting of polystyrene (PS) (core)/biosurfactants (shell) (50–190 nm) and their feasibility as a biocompatible and biodegradable drug delivery vehicle. RESULTS: Conversion profile, particle size dependence on biosurfactant concentration and structural characterizations of resulting polymers from bioinspired emulsion polymerization were similar to conventional emulsion polymerization. In vitro biodegradation studies revealed >2.5‐fold increase in bacterial growth ( Pseudomonas aeruginosa MTCC 7926) and gravimetric weight loss (10% w/w) in biosurfactants templated PS, compared with the conventional route. Soil burial biodegradation tests supported these findings. In vitro and in viv o biocompatibility studies showed unchanged cell viability of adult rat ( Rattus norvegicus ) hepatocytes for polystyrenes synthesized using biosurfactants, while conventional PS beads proved to be cytotoxic in a dose‐dependent manner. Reactive oxygen species (ROS)‐induced oxidative stress, increased lipid peroxidation, alterations in GSH detoxification and histopathology corroborated these results. Release of bovine serum albumin (BSA) from BSA loaded polystyrene/biosurfactant bionanocomposites were 2.5–5‐fold higher in physiological buffer (pH 7.4) than in acidic buffer (pH 1.2). CONCLUSION: Taken together, polystyrene/biosurfactant bionanocomposites could serve as a biocompatible and biodegradable colon or intestine‐specific drug delivery vehicle. © 2012 Society of Chemical Industry