Multi-stimuli responsive supramolecular hydrogels based on Fe3+ and diblock copolymer micelle complexation. Issue 7 (14th January 2016)

• Record Type: Journal Article
• Authors: Tao, Zhen; Peng, Kang; Fan, Yujiao; Liu, Yunfei; Yang, Haiyang
• Is Part Of: Polymer chemistry. Volume 7:Issue 7(2016)
• Page Start: 1405
• Page End: 1412
• Publication Date: 2016-01-14
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c5py01742d
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : We report a multi-stimuli responsive supramolecular hydrogel with great potential for biomedical application, which was composed of the micelle-forming diblock copolymer and physically cross-linked by complexation between ferric ions and carboxylic acid groups, exhibiting gel–sol transition caused by UV irradiation, multidentate ligands (EDTA) and redox agents (Na2 S2 O4 ). Abstract : Stimuli-triggered degradable hydrogels have found broad applications in controlled release of drugs, fragrances, flavourings and fertilizers. Recently, multi-stimuli responsive micelle-based hydrogels have gained focus, since they could respond to a combination of external stimuli. Herein, a multi-stimuli responsive supramolecular hydrogel with great potential for biomedical application was prepared, which was composed of the micelle-forming diblock copolymer poly[( N -isopropylacrylamide- co -2-nitrobenzyl acrylate)- block -( N, N -dimethylacrylamide- co -acrylic acid)] (P(NIPAM- co -NBA)- b -P(DMA- co -AA)), and physically cross-linked by supramolecular complexation between AA groups and ferric ions (Fe 3+ ), exhibiting gel–sol transition caused by UV irradiation, multidentate ligands (EDTA) and redox agents (Na2 S2 O4 ).