Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?. (7th February 2017)

• Record Type: Journal Article
• Authors: O'Mahony, S.M.; Clarke, G.; Dinan, T.G.; Cryan, J.F.
• Is Part Of: Neuroscience. Volume 342(2017)
• Page Start: 37
• Page End: 54
• Publication Date: 2017-02-07
• Subjects: ASD autism spectrum disorder -- BMI body mass index -- HPA hypothalamic–pituitary–adrenal -- IBD inflammatory bowel disease -- IBS irritable bowel syndrome; early-life -- brain development -- stress -- brain–gut axis -- microbiota; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2015.09.068
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Vulnerable neurodevelopmental windows exist during the life span. Adverse events during these times include altered gut microbiota. Increased knowledge about parallel colonization events and brain development is required. This is essential from a preventative, diagnostic and therapeutic perspective. Abstract: The prenatal and postnatal early-life periods are both dynamic and vulnerable windows for brain development. During these important neurodevelopmental phases, essential processes and structures are established. Exposure to adverse events that interfere with this critical sequence of events confers a high risk for the subsequent emergence of mental illness later in life. It is increasingly accepted that the gastrointestinal microbiota contributes substantially to shaping the development of the central nervous system. Conversely, several studies have shown that early-life events can also impact on this gut community. Due to the bidirectional communication between the gut and the brain, it is possible that aberrant situations affecting either organ in early life can impact on the other. Studies have now shown that deviations from the gold standard trajectory of gut microbiota establishment and development in early life can lead not only to disorders of the gastrointestinal tract but also complex metabolic and immune disorders. These are being extended to disorders of the central nervous system and understanding how the gut microbiome shapes brain and behavior during early life is an important new frontier in neuroscience.