A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids. (5th February 2017)

• Record Type: Journal Article
• Authors: Pretorius, Elzette; Arlt, Wiebke; Storbeck, Karl-Heinz
• Is Part Of: Molecular and cellular endocrinology. Volume 441(2017)
• Page Start: 76
• Page End: 85
• Publication Date: 2017-02-05
• Subjects: Adrenal androgens -- Castration resistant prostate cancer (CRPC) -- Congenital adrenal hyperplasia (CAH) -- Polycystic ovary syndrome (PCOS) -- 11-Ketotestosterone (11KT) -- 11-Ketodihydrotestosterone (11KDHT); Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2016.08.014
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has demonstrated that 11OHA4 is the precursor to the potent androgenic 11-oxygenated steroids, 11-ketotestosterone and 11-ketodihydrotestosterone, that bind and activate the human androgen receptor similarly to testosterone and DHT. The significance of this discovery becomes apparent when considering androgen dependent diseases such as castration resistant prostate cancer and diseases associated with androgen excess, e.g. congenital adrenal hyperplasia and polycystic ovary syndrome. In this review we describe the production and metabolism of 11-oxygenated steroids. We subsequently discuss their androgenic activity and highlight the putative role of these androgens in disease states. Highlights: 11OHA4 is the precursor to the potent androgens 11KT and 11KDHT. 11-oxygenated C19 steroids likely play a role in androgen related disease states. 11-oxygenated steroids are potentially useful biomarkers.