Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line. (2016)

• Record Type: Journal Article
• Authors: Somno, Aoranit; Anuchapreeda, Songyot; Chruewkamlow, Nuttapol; Pata, Supansa; Kasinrerk, Watchara; Chiampanichayakul, Sawitree
• Is Part Of: Leukemia research reports. Volume 6(2016)
• Page Start: 33
• Page End: 38
• Publication Date: 2016
• Subjects: Multidrug resistance -- Leukemia -- P-glycoprotein -- CD147; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2016.08.001
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: The relationship between P-gp and CD147 in the regulation of MDR in leukemic cells has not been reported. This study aimed to investigate the correlation between CD147 and P-gp in the regulation of drug resistance in the K562/ADR leukemic cell line. The results showed that drug-resistant K562/ADR cells expressed significantly higher P-gp and CD147 levels than drug-free K562/ADR cells. To determine the regulatory effect of CD147 on P-gp expression, anti-CD147 antibody MEM-M6/6 significantly decreased P-gp and CD147 mRNA and protein levels. This is the first report to show that CD147 mediates MDR in leukemia through the regulation of P-gp expression. Highlights: High expression levels of P-gp and CD147 in drug-resistant cells. MEM-M6/6 antibody decreases both CD147 and P-gp expression. CD147 mediates MDR phenotype in leukemia through the regulation of P-gp expression.