Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report. (2016)

• Record Type: Journal Article
• Authors: Vshyukova, Volha; Meleshko, Alexander; Mihal, Natalia; Aleinikova, Olga
• Is Part Of: Leukemia research reports. Volume 6(2016)
• Page Start: 15
• Page End: 19
• Publication Date: 2016
• Subjects: Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2016.06.005
• Languages: English
• ISSNs: 2213-0489

Abstract

Highlights: The case demonstrated a rare event of clonal heterogeneity by IKZF1 gene status in BCRABL1- ALL. IKZF1 deletions are secondary events in ALL caused by clonal evolution during the treatment. It's prognostic significance could be more crucial in BCR-ABL- rather than in BCR-ABL + ALL. IKZF1 gene alterations may be determined and proved at the genome, expression and protein level. IKZF1 deletions are suitable for MRD detection but not stable compared to Ig/TCR rearrangement.