A sensitive fluorescent probe for cysteine and Cu2+ based on 1, 8-naphthalimide derivatives and its application in living cells imaging. Issue 4 (26th January 2017)

• Record Type: Journal Article
• Authors: Shen, Ronghua; Yang, JingJing; Luo, Hong; Wang, Bingxiang; Jiang, Yuliang
• Is Part Of: Tetrahedron. Volume 73:Issue 4(2017)
• Page Start: 373
• Page End: 377
• Publication Date: 2017-01-26
• Subjects: 1, 8-Naphthalimide-based derivatives -- Fluorescent probe -- Detection limits -- Cells imaging; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2016.12.016
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A new 1, 8-naphthalimide derivative (NAD) was synthesized and employed as a highly sensitive and selective probe for the detection of cysteine (Cys) and Cu 2+ . The terminal olefin of NAD could react with Cys and resulting in fluorescence quenching, with the adding of Cu 2+, the schiff base unit of NAD could coordinate with Cu 2+ and lead to a highly selective fluorescence "turn-on" response. The detection limits reached as low as 25 nM for Cys and 11 nM for Cu 2+ . In addition, the NAD probe can be further applied to cells imaging owing to its photostability and low cytotoxicity. Graphical abstract: 1, 8-naphthalimide derivative (NAD) was developed for highly sensitive and selective detection of Cys and Cu 2+ with the detection limits as 25 nM for Cys and 11 nM Cu 2+ . In addition, the NAD probe can be further applied to cell imaging owing to its photostability and low cytotoxicity.