Metal-based ethanolamine-derived compounds: a note on their synthesis, characterization and bioactivity. (4th November 2016)

• Record Type: Journal Article
• Authors: Amjad, Muhammad; Sumrra, Sajjad H.; Akram, Muhammad Safwan; Chohan, Zahid H.
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 31(2016.)Supplement 4
• Page Start: 88
• Page End: 97
• Publication Date: 2016-11-04
• Subjects: Antibacterial/antifungal -- ethanolamine-derived compounds -- metal(II) complexes; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2016.1220375
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: Metal-based ethanolamines, (L 1 )–(L 4 ) coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals in 1:2 (metal:ligand) molar ratio to produce new compounds have been reported. These compounds were screened for their bactericidal/fungicidal activity against a number of bacterial ( Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis ) and fungal strains ( Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata ) alongside against a shrimp species known as Artemia salina . The screening results indicated that metal complexes have significantly higher activity than uncomplexed ligands against one or more bacterial/fungal species due to chelation. The ligand (L 4 ) displayed good bacterial and fungal activity as compared to other ligands. The antibacterial results revealed that the Zn(II) complex(16) of (L 4 ) was found to be the most active complex and Co(II) complex(14) of the same ligand (L 4 ), demonstrated the highest antifungal activity.