Activation of arginine vasopressin receptor 1a facilitates the induction of long-term potentiation in the accessory olfactory bulb of male mice. (10th November 2016)

• Record Type: Journal Article
• Authors: Namba, Toshiharu; Taniguchi, Mutsuo; Murata, Yoshihiro; Tong, Jia; Wang, Yujie; Okutani, Fumino; Yamaguchi, Masahiro; Kaba, Hideto
• Is Part Of: Neuroscience letters. Volume 634(2016)
• Page Start: 107
• Page End: 113
• Publication Date: 2016-11-10
• Subjects: ACSF artificial cerebrospinal fluid -- AOB accessory olfactory bulb -- AVP arginine vasopressin -- AVPR AVP receptor -- DCG-IV (2S, 1′R, 2′R, 3′R)-2-(2, 3-dicarboxycyclopropyl) glycine -- EPL external plexiform layer -- fEPSP field excitatory postsynaptic potential -- IPSC inhibitory postsynaptic current -- LOT lateral olfactory tract -- MOB main olfactory bulb -- NMDA N-methyl-d-aspartate -- PO-VT [Phe2, Ile3, Orn8]-vasopressin -- TTX tetrodotoxin; Vasopressin -- Vasopressin receptor -- Accessory olfactory bulb -- Long-term potentiation -- Reciprocal synapse -- Dendrodendritic inhibition; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2016.09.056
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: AVP with subthreshold tetanus promotes LTP induction in accessory olfactory bulb (AOB). AVP-paired long-term potentiation (LTP) is mediated by AVP receptor 1a. Arginine vasopressin (AVP) reduces self-inhibition of mitral cells. Abstract: Olfaction plays an important role in social recognition in most mammals. Central arginine vasopressin (AVP) plays a role in this olfaction-based recognition. The high level of expression of AVP receptors in the accessory olfactory bulb (AOB) at the first relay of the vomeronasal system highlights the importance of AVP signaling at this stage. We therefore analyzed the effects of AVP on the synaptic plasticity of glutamatergic transmission from mitral cells to granule cells in AOB slices from male mice. To monitor the strength of the glutamatergic transmission, we measured the maximal initial slope of the lateral olfactory tract-evoked field potential, which represents the granule cell response to mitral cell activation. AVP paired with 100-Hz stimulation that only produced short-term potentiation enhanced the induction of long-term potentiation (LTP) in a dose-dependent manner. AVP-paired LTP was blocked by the selective AVP receptor 1a (AVPR1a) antagonist, d(CH2 )5 [Tyr(Me) 2 ]AVP (Manning compound), but not by the AVPR1b antagonist SSR149415, and it was mimicked by the selective AVPR1a agonist [Phe 2, Ile 3, Orn 8 ]-vasopressin. We further examined the effect of AVP on the reciprocal transmission between mitral and granule cells by stimulating a mitral cell and recording the evoked inhibitory postsynaptic currents (IPSCs) from the same cell using conventional whole-cell patch-clamp techniques. AVP reduced the reciprocal IPSCs triggered by endogenous glutamate release from the excited mitral cell. These results suggest that AVP promotes the induction of LTP at the mitral-to-granule cell synapse via the activation of AVPR1a through an as-yet-to-be-determined mechanism in the AOB of male mice.