Copper-catalyzed synthesis of 2-sulfenylindoles from indoline-2-thiones and aryl iodides. Issue 4 (25th January 2017)

• Record Type: Journal Article
• Authors: Zhou, Shiping; Xiao, Genhua; Liang, Yun
• Is Part Of: Tetrahedron letters. Volume 58:Issue 4(2017)
• Page Start: 338
• Page End: 341
• Publication Date: 2017-01-25
• Subjects: Indoline-2-thiones -- Copper -- 2-Sulfenylindoles -- Benzothieno[2, 3-b]indoles; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.12.028
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A novel and efficient method for synthesis of 2-sulfenylindoles. Copper-catalyzed the formation of C–S bond. Extend to synthesize benzothiophene fused indoles. Abstract: A novel and efficient method for synthesis of 2-sulfenylindole via copper-catalyzed coupling reaction of indoline-2-thiones with aryl iodides has been developed. A series of N-substituted and N-free 2-sulfenylindole were obtained in high yields. Furthermore, the method was employed to synthesis of benzothieno[2, 3- b ]indoles from indoline-2-thiones with 1, 2-diiodobenzene in the presence of CuI and Pd(OAc)2 as catalysts.