Clinical and pathogenic features of SCCmec type II and IV methicillin-resistant Staphylococcus aureus in Japan. Issue 2 (February 2017)

• Record Type: Journal Article
• Authors: Mitsumoto-Kaseida, Fujiko; Murata, Masayuki; Toyoda, Kazuhiro; Morokuma, Yuiko; Kiyosuke, Makiko; Kang, Dongchon; Furusyo, Norihiro
• Is Part Of: Journal of infection and chemotherapy. Volume 23:Issue 2(2017:Feb.)
• Page Start: 90
• Page End: 95
• Publication Date: 2017-02
• Subjects: MRSA -- SCCmec type II -- SCCmec type IV -- Pneumonia -- Skin infection -- ST764 SCCmec type II clone; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2016.11.001
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: Staphylococcal chromosomal cassette mec (SCC mec ) type IV methicillin-resistant Staphylococcus aureus (MRSA) has rapidly disseminated in healthcare settings, and its characteristics in the United States and Europe are well known. Because Japanese SCC mec type IV MRSA clones are different and less well documented, this retrospective, single center study was done to determine and compare the characteristics of SCC mec type II and IV MRSA in Japan. For the analysis, 55 SCC mec type II and 101 type IV MRSA samples were collected from lower respiratory tract specimens or from skin or soft tissue. The patients of the SCC mec type IV group were significantly younger than those of the type II group ( P < 0.001). The rate of MRSA pneumonia was significantly lower for SCC mec type IV than for type II (7.8% vs 29.0%, P = 0.026). In contrast, the rate of skin and soft tissue infection was not significantly different (66.0% vs 61.9%, P = 0.788). The distribution of MRSA pathogenic genes ( sea, seb, sem, seo ) was significantly different between SCC mec types II and IV ( P < 0.001), which indicates that their clonal complex may be completely different. Interestingly, all SCC mec type II MRSA that caused MRSA pneumonia had seb and egc and lacked tst that belonged to sequence type (ST) 764. This is the first study to reveal and compare the characteristics of Japanese SCC mec type II and type IV MRSA. The information from this study will be helpful for the management of Japanese MRSA infection.