Unlocking the chromatin code by deciphering protein–DNA interactions. Issue 11 (11th November 2016)

• Record Type: Journal Article
• Authors: Bensaddek, Dalila; Lamond, Angus I
• Is Part Of: Molecular systems biology. Volume 12:Issue 11(2016:Nov.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-11-11
• Subjects: Molecular biology -- Periodicals; Systems biology -- Periodicals; 572.8
• DOI: 10.15252/msb.20167332
• Languages: English
• ISSNs: 1744-4292

Abstract

Abstract : Characterizing the composition of protein complexes bound to different genomic loci is essential for advancing our mechanistic understanding of transcriptional regulation. In their recent study, Krijgsveld and colleagues (Rafiee et al, 2016 ) report ChIP‐SICAP, a powerful tool for deciphering the chromatin proteome by combining chromatin immunoprecipitation, selective isolation of chromatin‐associated proteins and mass spectrometry. Abstract : Characterizing the chromatin proteome is essential for understanding transcriptional regulation. To this end, Krijgsveld and colleagues (Rafiee et al, 2016 ) report ChIP‐SICAP, a method combining ChIP, isolation of chromatin‐associated proteins and mass spectrometry.