Time course of hepatitis E‐specific antibodies in adults. Issue 1 (4th October 2016)

• Record Type: Journal Article
• Authors: Schemmerer, M.; Rauh, C.; Jilg, W.; Wenzel, J. J.
• Is Part Of: Journal of viral hepatitis. Volume 24:Issue 1(2017)
• Page Start: 75
• Page End: 79
• Publication Date: 2016-10-04
• Subjects: antibody dynamics -- anti‐HEV IgG -- hepatitis E virus -- negative seroconversion -- reinfection; Hepatitis, Viral -- Periodicals; Hepatitis, Viral, Animal; Hepatitis, Viral, Human; 616.3623
• DOI: 10.1111/jvh.12621
• Languages: English
• ISSNs: 1352-0504

Abstract

Summary: Hepatitis E virus (HEV) is highly endemic in industrialized countries, but there is a lack of knowledge on individual and overall antibody concentration dynamics. The aim of this study was to characterize longitudinal concentration changes of anti‐HEV immunoglobulin G (anti‐HEV IgG) by enzyme immunoassay (EIA). In total, 199 serum samples collected from 45 subjects over 18 years were analysed. A wide range of anti‐HEV IgG levels was found. Overall, anti‐HEV IgG significantly decreased after an observation period of at least 5 years. One negative seroconversion was observed. Four individual profiles suggested single and even multiple HEV reinfections despite pre‐existing HEV antibodies.