Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes. Issue 1 (2nd September 2016)

• Record Type: Journal Article
• Authors: Almond-Thynne, Joshua; Blakemore, David C.; Pryde, David C.; Spivey, Alan C.
• Is Part Of: Chemical science. Volume 8:Issue 1(2017)
• Page Start: 40
• Page End: 62
• Publication Date: 2016-09-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6sc02118b
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources and Pfizer's global chemistry RKB and CAS Scifinder® databases, factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends. Abstract : Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.