One-pot transition-metal-free cascade synthesis of thieno[2, 3-c]coumarins from chromones. Issue 106 (1st November 2016)

• Record Type: Journal Article
• Authors: Yang, Yuhong; Qi, Xueyu; Liu, Ruiling; He, Qian; Yang, Chunhao
• Is Part Of: RSC advances. Volume 6:Issue 106(2016)
• Page Start: 103895
• Page End: 103898
• Publication Date: 2016-11-01
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra21776a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A one-pot transition-metal-free, base-mediated synthesis of a novel series of functionalized thieno[2, 3- c ]coumarins has been developed through a cascade reaction from chromones. Abstract : A one-pot transition-metal-free, base-mediated synthesis of a novel series of functionalized thieno[2, 3- c ]coumarins via a cascade reaction from chromones has been developed. This cascade reaction involves a Michael addition–Knoevenagel condensation–intramolecular cyclization. This transformation proceeds under mild conditions and gives various thieno[2, 3- c ]coumarins in good-to-excellent yields. The methodology is tolerant of a wide range of functional groups and applicable to library synthesis.