Synthesis of water-dispersible silicon-containing hydroxyapatite nanoparticles with adjustable degradation rates and their applications as pH-responsive drug carriers. Issue 115 (13th December 2016)

• Record Type: Journal Article
• Authors: Lin, Kaili; Zhang, Na; Yin, Zhilan; Shen, Yuhui; Zhang, Weibin
• Is Part Of: RSC advances. Volume 6:Issue 115(2016)
• Page Start: 114852
• Page End: 114858
• Publication Date: 2016-12-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra24005d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An environmentally friendly method was developed to synthesize water-dispersible Si-HAp nanoparticles with adjustable degradation rates, high loading capacities for anticancer drugs, and sustained and pH-dependent drug release properties. Abstract : Silicon-containing hydroxyapatite (Si-HAp) nanoparticles with adjustable degradation rates were successfully synthesized via simple hydrothermal treatment of a precursor, calcium silicate hydrate powder, in trisodium phosphate aqueous solution. The degradation rate of the products could be facilely tailored by regulating the hydrothermal temperature, while the obtained Si-HAp nanoparticles exhibited high loading capacities toward doxorubicin (DOX) as well as sustained and pH-dependent drug release properties. HeLa cell culture results confirmed that the toxicity of DOX loaded in Si-HAp nanoparticles was more sustained than that of free DOX. Their biodegradability, good water dispersibility and drug-loading capacity, and sustained and pH-responsive drug release properties suggest that these synthetic Si-HAp nanoparticles have great potential applications as drug carriers.