Deployment-Associated Exposure Surveillance With High-Resolution Metabolomics. (August 2016)

• Record Type: Journal Article
• Authors: Walker, Douglas I.; Mallon, COL Timothy M.; Hopke, Philip K.; Uppal, Karan; Go, Young-Mi; Rohrbeck, Patricia; Pennell, Kurt D.; Jones, Dean P.
• Is Part Of: Journal of occupational and environmental medicine. Volume 58:(2016)Supplement 1 8S
• Publication Date: 2016-08
• Subjects: Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational Medicine -- Periodicals; Environmental Medicine -- Periodicals; Environmental health; Medicine, Industrial; Periodicals; Electronic journals; 616.9803
• DOI: 10.1097/JOM.0000000000000768
• Languages: English
• ISSNs: 1076-2752

Abstract

Abstract : Objective: The aim of this study was to assess the suitability of high-resolution metabolomics (HRM) for measure of internal exposure and effect biomarkers from deployment-related environmental hazards. Methods: HRM provides extensive coverage of metabolism and data relevant to a broad spectrum of environmental exposures. This review briefly describes the analytic platform, workflow, and recent applications of HRM as a prototype environmental exposure surveillance system. Results: Building upon techniques available for contemporary occupational medicine and exposure sciences, HRM methods are able to integrate external exposures, internal body burden of environmental agents, and relevant biological responses with health outcomes. Conclusions: Systematic analysis of existing Department of Defense Serum Repository samples will provide a high-quality, cross-sectional reference dataset for deployment-associated exposures while at the same time establishing a foundation for precision medicine.