Synthesis and antiproliferative efficiency of novel bis(imidazol-1-yl)vinyl-1, 2, 4-oxadiazoles. (29th January 2016)

• Record Type: Journal Article
• Authors: Nandeesh, Kebballi N.; Swarup, Hassan A.; Sandhya, Nagarakere C.; Mohan, Chakrabhavi D.; Pavan Kumar, Chottanahalli S.; Kumara, Manikyanahalli N.; Mantelingu, Kempegowda; Ananda, Sannaiah; Rangappa, Kanchugarakoppal S.
• Is Part Of: New journal of chemistry. Volume 40:Number 3(2016:Mar.)
• Page Start: 2823
• Page End: 2828
• Publication Date: 2016-01-29
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c5nj02925b
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A new class of bis(imidazol)vinyl-1, 2, 4-oxadiazoles were synthesised and their anti-proliferative efficiency was tested against HCT116 and A549 cancer cell lines. Abstract : A new approach for the synthesis of novel bis(imidazol-1-yl)vinyl-1, 2, 4-oxadiazoles has been developed. This method operates in a single step giving the products in good to excellent yields. Antiproliferative efficiency of the synthesized compounds was tested against HCT116 (colon cancer) and A549 (lung cancer) cell lines. Among them, compounds3m (IC50, 9.7 μM) and3h (IC50, 20.3 μM) were found to be the best antiproliferative agents.