Xanthurenic acid: a natural ionophore with high selectivity and sensitivity for potassium ions in an aqueous solution. (4th January 2016)

• Record Type: Journal Article
• Authors: Raju, M.; Patel, Tapasya J.; Nair, Ratish R.; Chatterjee, Pabitra B.
• Is Part Of: New journal of chemistry. Volume 40:Number 3(2016:Mar.)
• Page Start: 1930
• Page End: 1934
• Publication Date: 2016-01-04
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c5nj02540k
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Synopsis: A well-known tryptophan metabolite, xanthurenic acid, a natural non-fluorescent intermediate siderophore, showed a very selective turn-on response to K + over other competing metal ions and the detection limit of this natural ionophore was found to be 53 nM at physiological pH. Abstract : Xanthurenic acid (H3 L ), a simple natural molecule and a well known tryptophan metabolite involved in the biosynthesis of quinolobactin siderophore, was developed as an efficient "turn-on" fluorosensor for potassium ions in aqueous HEPES buffer solutions. The natural ionophore, H3 L, showed high selectivity for K + at physiological pH and in the context of interference from other competing metal ions, particularly Na +, the specific response ofH3 L towards K + did not change. The detection limit was found to be 53 nM. This study demonstrates the first example in which a non-cyclic system bearing monocarboxylate functionality was used as an efficient fluorosensor for the detection of K + in water.