Benzylation of heterocyclic N-oxides via direct oxidative cross-dehydrogenative coupling with toluene derivatives. (3rd November 2016)

• Record Type: Journal Article
• Authors: Wan, L.; Qiao, K.; Sun, X. N.; Di, Z. C.; Fang, Z.; Li, Z. J.; Guo, K.
• Is Part Of: New journal of chemistry. Volume 40:Number 12(2016:Dec.)
• Page Start: 10227
• Page End: 10232
• Publication Date: 2016-11-03
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c6nj02560a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A novel cross-dehydrogenative coupling (CDC) of heterocyclic N-oxides with toluene derivatives has been disclosed. Abstract : A novel cross-dehydrogenative coupling (CDC) of heterocyclic N-oxides with toluene derivatives has been discussed, allowing for the facile synthesis of a broad range of structurally diverse C1-benzyl quinoline N-oxides, isoquinoline N-oxides and pyridine N-oxides, including two methylated quinoline N-oxides in particular. This protocol not only extends the application of toluenes in synthetic organic chemistry, but also offers an alternative method to prepare benzylated heterocyclic N-oxides without any metal involved, which is important in medicinal chemistry.