Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates. (2nd January 2017)

• Record Type: Journal Article
• Authors: Mahmoud, Sawsan; Li, Hao; McBrayer, Tamara R.; Bassit, Leda; Hammad, Sherif F.; Coats, Steven J.; Amblard, Franck; Schinazi, Raymond F.
• Is Part Of: Nucleosides, nucleotides & nucleic acids. Volume 36:Number 1(2017)
• Page Start: 66
• Page End: 82
• Publication Date: 2017-01-02
• Subjects: Fluorine -- acyclonucleoside -- phosphoramidates -- antiviral agent; Nucleosides -- Periodicals; Nucleotides -- Periodicals; Nucleic acids -- Periodicals; 572.8
• DOI: 10.1080/15257770.2016.1218023
• Languages: English
• ISSNs: 1525-7770

Abstract

ABSTRACT: A novel series of tetrafluoro and hexafluoro acyclic nucleosides and their phosphoramidates were successfully prepared from commercially available 2, 2, 3, 3-tetrafluoro-1, 4-butanediol and 2, 2, 3, 3, 4, 4-hexafluoro-1, 5-pentanediol in four to six steps. Their ability to block HIV, HCV, HSV-1, and HBV replication along with their cytotoxicity toward HepG2, human lymphocyte, CEM, and Vero cells was assessed.