Traffic-related air pollution increased the risk of Parkinson's disease in Taiwan: A nationwide study. (November 2016)

• Record Type: Journal Article
• Authors: Lee, Pei-Chen; Liu, Li-Ling; Sun, Yu; Chen, Yu-An; Liu, Chih-Ching; Li, Chung-Yi; Yu, Hwa-Lung; Ritz, Beate
• Is Part Of: Environment international. Volume 96(2016:Nov.)
• Page Start: 75
• Page End: 81
• Publication Date: 2016-11
• Subjects: PD Parkinson's disease -- ORs odds ratios -- CIs confidence intervals -- COX2 cyclooxygenase 2 -- IL-1β interleukin-1β -- O3 ozone -- PM2.5 particulate matter with an aerodynamic diameter ≦ 2.5 μm -- PM10 particulate matter with an aerodynamic diameter ≦ 10 μm -- NOx nitrogen oxides -- CO carbon monoxide -- SO2 sulfur dioxide -- IRB Institutional Review Board -- NHRI National Health Research Institute -- NHIRD National Health Insurance Research Database -- iPD idiopathic PD -- QBME quantile-based Bayesian Maximum Entropy -- IQR interquartile range increase -- COPD chronic obstructive pulmonary disease -- CCI Charlson Comorbidity Index; Ambient air pollution -- Parkinson's disease; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2016.08.017
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Background: Ambient air pollution has been associated with many health conditions, but little is known about its effects on neurodegenerative diseases, such as Parkinson's disease (PD). In this study, we investigated the influence of ambient air pollution on PD in a nationwide population-based case–control study in Taiwan. Methods: We identified 11, 117 incident PD patients between 2007 and 2009 from the Taiwanese National Health Insurance Research Database and selected 44, 468 age- and gender-matched population controls from the longitudinal health insurance database. The average ambient pollutant exposure concentrations from 1998 through the onset of PD were estimated using quantile-based Bayesian Maximum Entropy models. Basing from logistic regression models, we estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of ambient pollutant exposures and PD risk. Results: We observed positive associations between NOx, CO exposures, and PD. In multi-pollutant models, for NOx and CO above the 75th percentile exposure compared with the lowest percentile, the ORs of PD were 1.37 (95% CI = 1.23–1.52) and 1.17 (95% CI = 1.07–1.27), respectively. Conclusions: This study suggests that ambient air pollution exposure, especially from traffic-related pollutants such as NOx and CO, increases PD risk in the Taiwanese population. Highlights: Traffic-related pollutants NOx and CO increase the risk of PD. High levels of coarse particles contribute to the increased risk of PD. Traffic-related air pollution may adversely affect the aging brain.