Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes. (1st November 2016)

• Record Type: Journal Article
• Authors: Wahba, Nashwa S.; Shaban, Sahar F.; Kattaia, Asmaa A. A.; Kandeel, Sara A.
• Is Part Of: Ultrastructural pathology. Volume 40:Number 6(2016:Dec.)
• Page Start: 358
• Page End: 373
• Publication Date: 2016-11-01
• Subjects: Diabetes -- histopathology -- rat -- pancreas -- zinc oxide nanoparticles; Pathology, Cellular -- Periodicals; Ultrastructure (Biology) -- Periodicals; Diagnosis, Electron microscopic -- Periodicals; Microscopy, Electron; Pathology; 616.07582
• DOI: 10.1080/01913123.2016.1246499
• Languages: English
• ISSNs: 0191-3123

Abstract

ABSTRACT: Zinc oxide nanoparticles (ZnO NPs) therapy is a promising strategy for treatment of several diseases. We aimed to investigate the therapeutic potential of ZnO NPs in ameliorating the histopathological and functional alterations in the pancreas of a rat model of streptozotocin-induced diabetes. Rats were randomized into control, diabetic and ZnO NPs-treated diabetic groups. Biochemical assays of blood glucose and serum insulin were performed. Pancreas specimens were processed for light and electron microscope examinations. ZnO NPs effectively reversed diabetes-induced pancreatic injury, as evidenced by the structural and ultrastructural improvement and confirmed by biochemical normalization of blood glucose and serum insulin.