Hereditary lactate dehydrogenase M‐subunit deficiency with late‐developing pustular psoriasis‐like lesions. Issue 12 (23rd July 2016)

• Record Type: Journal Article
• Authors: Takeo, Naoko; Fujiwara, Sakuhei; Sakai, Takashi; Saito‐Shono, Tomoko; Ishikawa, Kazushi; Hatano, Yutaka
• Is Part Of: Journal of dermatology. Volume 43:Issue 12(2016)
• Page Start: 1429
• Page End: 1432
• Publication Date: 2016-07-23
• Subjects: lactate dehydrogenase -- lactate dehydrogenase‐M subunit deficiency -- nicotinamide adenine dinucleotide -- pellagra -- pustular psoriasis; Dermatology -- Periodicals; Dermatology -- Japan -- Periodicals; Skin -- Diseases -- Periodicals; 616.5005
• DOI: 10.1111/1346-8138.13516
• Languages: English
• ISSNs: 0385-2407

Abstract

Abstract: Hereditary lactate dehydrogenase (LDH) M‐subunit deficiency is very rare and we have found reports of close to a dozen cases in the published work, two of which were associated with pustular psoriasis‐like lesions. We report a third case of pustular psoriasis‐like eruptions associated with LDH M‐subunit deficiency, which occurred 24 years after the diagnosis of LDH M‐subunit deficiency. These cases indicate that abnormal activity of LDH can induce pustular psoriatic lesions in the long term. Some patients with symptoms of hereditary LDH M‐subunit deficiency have antecedent annular scaly plaque lesions, that resemble psoriatic lesions. We discuss a hypothesis to explain this scenario.