Single nucleotide polymorphism of adiponectin +276 G/T is associated with the susceptibility to essential hypertension in a Turkish population. (16th November 2016)

• Record Type: Journal Article
• Authors: Demir, Ayşe Kevser; Kaya, Süheyla Uzun; Şahin, Şafak; Benli, İsmail; Bütün, İlknur; Erken, Ertuğrul; Tasliyurt, Turker
• Is Part Of: Clinical and experimental hypertension. Volume 38:Number 8(2016)
• Page Start: 686
• Page End: 690
• Publication Date: 2016-11-16
• Subjects: Adiponectin -- angiotensin II receptor 1 -- angiotensin-converting enzyme -- arterial stiffness -- endogenous nitric oxide synthase -- essential hypertension -- genetic polymorphism; Hypertension -- Chemotherapy -- Periodicals; Hypotensive agents -- Periodicals; 616.132
• DOI: 10.1080/10641963.2016.1200607
• Languages: English
• ISSNs: 1064-1963

Abstract

ABSTRACT: Background : It is well known that arterial stiffness is associated with hypertension. Recent studies have shown that adiponectin +276 G/T, ACE I/D, AGTR1 A1166C, and eNOS E298D polymorphisms are likely to be risk factors for arterial stiffness. In this study, we aimed to investigate possible associations between these single-nucleotide polymorphisms (SNPs) and essential hypertension in a Turkish population. Methods : The study population consisted of 170 patients who were diagnosed with essential hypertension and 170 sex- and age-matched controls. Genotyping of adiponectin +276 G/T, ACE I/D, AGTR1 A1166C, and eNOS E298D SNPs were performed using real-time polymerase chain reaction and commercially produced kits. Results : The percentage of the adiponectin +276 T allele carriers was significantly higher in the patients with hypertension (33%) than in the controls (25%, p < 0.011). Through multiple logistic regression analysis, the adiponectin +276 T allele carrier was found to be associated with an increased risk of hypertension (TT vs. GG and TG: odds ratio = 3.318, p = 0.014, 95% confidence interval: 1.269–8.678). The genotype distributions or allelic frequencies of ACE I/D, AGTR1 A1166C, and eNOS E298D SNPs did not significantly differ between the patients with hypertension and the controls. Conclusion : The present study demonstrated that the adiponectin +276 G/T SNP is likely to be a risk factor for essential hypertension in a Turkish population.