Synthesis, spectroscopic studies, antimicrobial activity, and crystal structure of a Zn(II) complex based on Voriconazole. Issue 2 (17th January 2017) - Zhao, Yan-Ming
Abstract: [Zn(FZ )2 Cl2 ] (1 ) (FZ = Voriconazole, (2 R, 3 S )-2-(2, 4-difluorophenyl)-3(5-fluoropyrimidin-4-yl)-1-(1 H -1, 2, 4-triazol-1-yl)butan-2-ol), has been obtained through the reaction of zinc chloride andFZ and has been characterized by FT-IR, UV–vis and fluorescence spectra, elemental analysis (EA), single crystal X-ray diffraction, powder X-ray diffraction and thermogravimetric analysis (TGA).FZ was also characterized by FT-IR, UV–vis spectra, single crystal X-ray diffraction and TGA.FZ crystallizes in the chiral space group P 21 and1 crystallizes in chiral space group P 1 with a mononuclear structure. In1, there are three kinds of hydrogen bonding interactions and weak stacking interactions which generate a 3-D architecture. The primary antimicrobial results show that1 exhibits potent activity against Aspergillus ( Aspergillus niger, Aspergillus terreus, Aspergillus fumigatus and Aspergillus flavus ) and Candida species ( Candida albicans, Candida krusei, Candida glabrata and Cryptococcus neoformans ), higher than that of freeFZ . Fluorescence spectra of1 andFZ have been discussed. Abstract :