Electrochemical studies and potential anticancer activity in ferrocene derivatives. Issue 2 (17th January 2017)

• Record Type: Journal Article
• Authors: Realista, Sara; Quintal, Susana; Martinho, Paulo N.; Melato, Ana I.; Gil, Adrià; Esteves, Teresa; Carvalho, Maria de Deus; Ferreira, Liliana P.; Vaz, Pedro D.; Calhorda, Maria José
• Is Part Of: Journal of coordination chemistry. Volume 70:Issue 2(2017)
• Page Start: 314
• Page End: 327
• Publication Date: 2017-01-17
• Subjects: Ferrocene -- cytotoxicity -- cyclic voltammetry -- DFT -- Mössbauer; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2016.1257125
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: Several ferrocene derivatives (five mononuclear and two binuclear), including the new N -( p -chlorophenyl)-carboxamidoferrocene (1 ), were synthesized and their anticancer activity investigated. Two of them, 3 and7, bearing a benzimidazole backbone were the most active against HeLa cells achieving IC50 values of ~5 μM along with4 with a dipyridylamine ligand (~6 μM). Complex6, also with a benzimidazole backbone, displayed slightly higher values (~11 μM). Cyclic voltammetry studies show that while the non-cytotoxic ferrocene derivatives1, 2, and5 follow a ferrocene-based redox behavior, derivatives3, 4, 6, and7 exhibit a more complex mechanism. These complex mechanisms are consistent with a more effective cytotoxic activity. Mössbauer spectroscopy parameters reflect a very small influence of the substituents. Abstract :