Multicomponent synthesis of hydrazino depsipeptides. Issue 102 (19th October 2016)

• Record Type: Journal Article
• Authors: Suć, Josipa; Barić, Danijela; Jerić, Ivanka
• Is Part Of: RSC advances. Volume 6:Issue 102(2016)
• Page Start: 99664
• Page End: 99675
• Publication Date: 2016-10-19
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra23317a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Hydrazino depsipeptides, a new class of backbone extended peptidomimetics were prepared by the Passerini reaction of α-hydrazino acids, carbonyl compounds and isocyanides. Abstract : The Passerini reaction of α-hydrazino acids, carbonyl compounds and isocyanides yielded hydrazino depsipeptides, a new class of backbone extended peptidomimetics comprising amide bond isostere. A wide range of carbonyl and isocyano components were used along the α-hydrazino acids carrying three different N α protecting groups. The kinetics and thermodynamic equilibrium of the rate-determining step of the reaction with different α-hydrazino acids were studied by DFT approach.