Elemental sulfur mediated synthesis of benzoxazoles, benzothiazoles and quinoxalines via decarboxylative coupling of 2-hydroxy/mercapto/amino-anilines with cinnamic acids. Issue 84 (26th August 2016)

• Record Type: Journal Article
• Authors: Guntreddi, Tirumaleswararao; Vanjari, Rajeshwer; Kumar, Saurabh; Singh, Rahul; Singh, Neetu; Kumar, Promod; Singh, Krishna Nand
• Is Part Of: RSC advances. Volume 6:Issue 84(2016)
• Page Start: 81013
• Page End: 81016
• Publication Date: 2016-08-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra17491d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A practical method has been developed for the synthesis of 2-benzylbenzoxazoles and 2-benzylbenzothiazoles using sulfur mediated decarboxylative coupling of cinnamic acids with 2-hydroxyanilines and 2-mercaptoanilines respectively. Abstract : An easy and practical method has been developed for the synthesis of 2-benzylbenzoxazoles and 2-benzylbenzothiazoles using sulfur mediated decarboxylative coupling of cinnamic acids with 2-hydroxyanilines and 2-mercaptoanilines respectively under metal- and solvent-free conditions. However, the reaction of 2-aminoanilines with cinnamic acids leads to the formation of 2-arylquinoxalines under the same set of reaction conditions. The transformation is versatile and compatible with a number of functional groups.